How to make DMT 3 Different Methods (N,N,DMT and 5-MeO-DMT)

How to make DMT 3 Different Methods (N,N,DMT and 5-MeO-DMT)

Make DMT 3 Different Methods: DMT (dimethyltryptamine) is among the most powerful and well-known psychedelics found on Earth.

The potent psychedelic is simple to create. The easiest method is to make it from plants that contain DMT however, it is also able to be created from ingredients that are readily available in the market with a basic knowledge of chemistry and access to basic lab equipment.

In this article we’ll discuss three distinct ways to create two types “DMT.”

We’ll go over the natural extraction technique (beginner level) and synthesizing 5MeO-DMT Hamilton Morris fashion (intermediate level) as well as an approach to creating the N-N DMT (advanced stage).

What exactly is DMT?

DMT is dimethyltryptamine It’s one of the most basic psychoactive substances at a molecular level however, it is also one of the most profound in terms of the sensation it creates. There are several types of DMT that are available, but the most well-known are the N,N,DMT and the 5-MeO-DMT.

Other forms are also available but they offer a totally distinct experience, for instance, the 4-AcO DMT (more comparable to psilocybin , but not as similar to DMT), 5-Bromo-DMT (very mildly psychoactive effects) as well as the 4-OH DMT (the chemical name of the chemical psilocin). These are technically considered to be a type of DMT however they are in distinct from N,N,DMT, or 5-MeO-DMT.

The most popular method of making use of DMT is through the form of the ayahuasca (N,N,DMT) and Bufo Alvariustoad (5-MeO-DMT). Both are the traditional sources of DMT utilized by shamans in order to trigger mystical experiences for healing and self-discovery.

DMT may also be used to smoke or vape creating an intense, but brief psychoactive experience.

Research has proven that DMT can effectively create mystical experiences that provide the potential to release deep emotional memories, pushing back personal beliefs and healing mental disease. DMT is being investigated as a therapy for existential anxiety addiction, depression, migraine headaches, anxiety and many more.

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How To Extract DMT from Plants

The most straightforward method to create DMT is by removing it from plant material. The most commonly used plant for this is Mimosa hostilis root bark, which is easily accessible on the internet. Many plant sources contain N,N and DMT in lieu of 5-MeO DMT or other psychoactive tryptamines. There are many other sources to consider in addition, like Acacia ConfusaPsychotria viridis and many others.

It is possible to run the extraction using the simplest materials available on the internet or in large box stores.

Here’s the summary:


  1. Plant material that contains DMTDMT-containing plant material – you can make use of Mimosa hostilis Mimosa pudica Psychotria viridisor other sources of plants for DMT
  2. An unipolar solvent for example, naphtha such as naphtha
  3. Distilled water
  4. Hydroxide of sodium (lye)
  5. 5 percent white vinegar distilled –can also be made using muriatic acid


  1. Nitrile gloves
  2. Goggles for safety
  3. A pipette, or separation funnel- to get rid of the nonpolar layer which contains DMT. DMT (separation funnels are great too)
  4. Filters used in coffee
  5. A handful of glass beakers or jars -for example -never use metal or plastic containers for these extractions
  6. A freezer and refrigerator
  7. Blender or coffee maker

The Process is simplified

  1. Mix plant material and water and vinegar
  2. Add sodium hydroxide in order to increase the pH
  3. Add naphtha to create a separation between the DMT part. Add naphtha to separate the DMT
  4. Put it in the refrigerator to make sure that the DMT
  5. Dry and filter your freebase DMT powder

Step-by-Step Method to Extract DMT from Plants

The fundamental method of getting DMT from sources in plants is straightforward and can be accomplished using chemicals that are easily available without the requirement for a laboratory license. There are a variety of alternatives for the chemicals that are used, and more advanced methods of purification such as short-path vacuum distillation may improve the efficiency of the process however they aren’t required.

The following procedure outlines the most straightforward method of DMT extraction that anyone can use at home.

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Most important thing to be aware of is that, even though they are readily accessible, the chemicals that are used for this process are extremely hazardous if not used correctly:

  1. Lye is acidic and can cause serious chemical burns to skin and eyes — use gloves and protective goggles.
  2. Naphtha as well as other solvents are extremely flammable Make sure to make sure the area is well-ventilated and free from open flames or sparks.
  3. Certain plants are poisonous They always make sure the plant material that is used to make the base comes from a reliable source so that you don’t extract the wrong plant species.

This is the step-by-step procedure to extract DMT from plants. It’s a straightforward method:

Step 1: Warm the plant material by soaking it in Water & Vinegar

Start with your ground plant materials, crush it to a fine powder using a coffee grinder or blender.

After that, slowly add 5% of distilled white vinegar into the herb powdered (ratio 0.4 milliliters per gram dried herbs). You can also make use of muriatic acid in this procedure.

Add close to boiling pure water (90oC) in an amount of 3.6 milliliters of water per grams of powdered dried roots.

The solution should be heated gently for 3 to 4 hours, stirring often. It is possible to use the two-boiler, hot plate or slow cooker to accomplish this. Set the heat on low, it should not be boiling.

Step 2. Strain to Detach the Plant Material

After about half an hour After a half-hour or so, you’ll be able to strain the plant substance from the mixture by using cheesecloth or a fine strainer. The liquid you’ll get is basically a tincture of the plant material that you used as the basis. It’ll be very dark and possess a strong scent.

Step 3: Basify The Solution

To make the solution basified to basify the solution, mix 5 grams of lye (sodium hydroxide) with 100 milliliters of water distilled. Check the pH to make sure that it’s between 12 and 13. The pH is higher than 12 when it changes from a deep purple to dark black.

The solution should be added to the extraction slowly -it will become darker and then begin to warm up. Allow the mixture to rest for around 48 hours prior to going to the next step.

Step 4. Filter and Defat

The process of defatting requires “washing” solutions using an unpolar solvent such as naphtha (found at camping stores in the form gasoline as well as Zippo liquid).

After adding the solvent and provide the mix with a good stir and a nonpolar phase will slowly begin floating to the top in the fluid. Allow the mixture to rest for 24 hours to let it completely separate. Make a light mix of the solution by gently shaking the jar every couple of hours. Be careful not to shake too much as the solution could begin to emulsify, making it much more difficult to separate.

In the span of a couple of hours, the DMT will be able to diffuse through the water layer up to the naphtha layer.

Step 5: Distinguish the top DMT-Containing Layer Rechrystalize

Using a pipetteor turkey baster or funnel for separation, you can separate the transparent upper layer of the DMT from its dark. The transparent upper layer contains where DMT is.

Put this solution inside the refrigerator to cool. Chrystals form at the bottom of the solution made up of almost 100% freebase DMT.

It is then possible to pour this mixture through a filter to remove the DMT chrystals from naphtha. Let the filters completely dry in a cool space to eliminate the naphtha.

Step 6: Recrystallization and Additional Purification

The product you’ve got in the moment can be consumed, however, it’s best to separate recrystallization of your extract to cleanse the extract even more.

This is accomplished by adding a tiny amount of naphtha in the powder, and then gently stirring until all the ingredients are dissolved. If it isn’t dissolved then you might need to gently heat the solution with an electric double boiler. Be cautious as the naptha is likely to begin to evaporate at about 40oC. Avoid using any open flames to warm the solution in any way.

Then, put the solution in the refrigerator for a couple of hours and then place it in the freezer for a couple of more hours.

It is important to let the solution slowly cool down by cooling it until room temp, then fridge temperature, then the freezer instead of simply taking it to the freezer straight. It’s not going to yield a great yield if you put the jar in the freezer.

After a couple of hours, after a few hours, DMT will begin to form new crystals on lower levels of the container that will be more pure than the initial set of crystals that you created in step 4.

Remove the crystals from the naphtha by using the help of a coffee filter. Place the powder on a plate , and let it to dry completely. Make sure there is enough ventilation so that naphtha is safely removed when it is evaporated out of the powder.

How pure is the final Extract?

The result is freebase N,N,DMT with a few other unknown compounds that were removed out of the facility.

This method is a secure method to produce high concentrations of DMT However, without any further lab purification methods this method will never be pure.

There are many other compounds within the plant which are removed using the same method. The specific compounds that are isolated depend on the origin of the plant’s raw materials, the solvents used and other variables.

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Where can I purchase DMT-Contained Plants?

DMT is in itself illegal all over the world However, the plants that have DMT aren’t as regulated. Eliminating plants with DMT would be challenging because there are many. Many DMT-containing plants are considered weeds, because of their weedy nature, therefore bans on them would be nearly impossible.

The most commonly used plants in the production of DMT comprise Mimosa hostilisPsychotria viridis and Acacia Confusa They are legal all over the world and thrive in warmer climates, and are purchased in large quantities on the internet.

Here are a few companies to consider:


DMT is a plant-based source.

  • Acacia maidenii bark — 0.36% N,N,DMT
  • Acacia simplicifolia bark — 0.86% N,N,DMT
  • Mimosa hostilis root (bark) — 0.57% N,N,DMT
  • Psychotria viridis’s aerial parts –0.4% 0.44 percent N,N,DMT
  • Desmanthus illinoensis root bark — 0.34 percent N,N,DMT
  • Pilocarpus organensis — 1.06 5MeO-DMT, a %
  • Phalaris tuberosa — 0.10$ N,N,DMT, 0.02% 5-MeO-DMT, 0.005% 5-OH-DMT
  • Phalaris arundinacea0.060% N,N,DMT — 0.060 percent N,N,DMT

How do you synthesize 5-MeO-DMT?

Synthesizing 5-MeO is more challenging than extracting it from plants , and requires more sophisticated lab equipment. But it’s a simple procedure that can be done efficiently and safely by those who have a basic understanding of the chemistry of lab procedures and.

Hamilton Morris released a video in 2021. It showcases a modified version the Eschweiler-Clarke reaction employing 5-methoxy-tryptamine for the base substance (already legally and commercially available).

The reaction is simple, requiring a complete change in only one reaction.

When the 5-MeO DMT is made the 5-MeO-DMT is purified, then further purified, and then tested.


  1. 5-Methoxy-Tryptamine
  2. Methanol
  3. Potassium Hydroxide
  4. Formaldehyde
  5. Sodium cyanoborohydride


  1. Reflux condenser
  2. Reaction chamber
  3. Rotary Evaporator
  4. Thermometer
  5. Two additional funnels

The Process is simplified

  1. Slowly mix 5-methoxy-tryptamine and formaldehyde with and sodium the cyanoborohydride
  2. Remove the 5-MeO-DMT which is floating up to the highest point.
  3. Purify by distillation and recrystallization
  4. Make sure you test the final sample

Step-By-Step Process:

The simplest method to create 5-MeO-DMT is by finding the source of 5-MeO-tryptamine freebase, a chemical that is completely legal and accessible from wholesalers or retailers of chemical products. The cost of this substance differs based the location you reside in.

Step 1: Dissolve the free 5-methoxytryptamine base in Methanol.

First, dissolve powdered 5-MeO-tryptamine into Methanol or another solvent in order to speed up the process. The chemical is readily accessible (legally) in the United States, and is mostly used to make the melatonin. This molecule needs a simple reduction reaction to make 5-MeO-DMT.

Step 2. Cool the Mixture until it is 0oC.

Utilizing an ice bath or chiller the reaction vessel and the 5-MeO tryptamine are chilled to the temperature of 0oC.

Step 3. Slowly Mix Formaldehyde and Sodium Cyoborohydride.

With two funnels of addition and slowly add the reducing agents in the vessel for reaction. The elements must be added slowly and continuously stirring.

Step 4: Remove the Methanol

Allow the mixture to cool overnight to evaporate the Methanol. When the methanol is evaporated, 5MeO DMT “oil slicks” appear over the top of the liquid.

Phase 5: Cleanse the 5-MeO DMT

Once the 5-MeO DMT has been produced, it must separate from other elements present in the mixture. Distillation is the process that removes the water. short-path vacuum distillation focuses the basic DMT freebase. The final step is recover the 5-MeO DMT by redissolving the extract in warm methanol before putting it in the refrigerator for a couple of days to form crystals at in the base of the vessel.

This mixture then gets dried, filtered and then examined for quality.

How to Synthesize N,N and DMT

Synthesizing N,N,DMT is by far the most complicated of the three techniques and requires a greater amount of experience and skill to work safely and efficiently.

Furthermore, the chemicals required for the extraction process are more difficult to find and are extremely flammable, toxic, and caustic.


  1. Oxalyl chloride
  2. Diethyl Ether
  3. Lithium aluminum hydroxide
  4. Ether
  5. Distilled water
  6. Tetrahydrofuran
  7. Dioxane
  8. Anhydrous magnesium sulfate
  9. Petroleum Ether
  10. Hydrogen chloride


  1. Reflux condenser
  2. Reaction vessel
  3. Separation filter

The Process Simplified

  1. Dissolve Tryptamine by Diethyl Ether
  2. React with reagents and form N,N,DMT
  3. Make the DMT Salt
  4. Re-crystallize and Remove All Solvents
  5. Make sure you test the final product

Step-by-Step Instructions to Synthesize N,N, and DMT

The procedure was described through Alexander Shulgin in his book, PIHKAL. This method requires some prior experience working in a lab, as well as access to various pieces of equipment for labs in order to safely perform.

Step 1. Dissolve the Tryptamine Diethyl Ether

It is the first thing to dissolve the precursor to N,N,DMT -tryptamine — using diethyl ether. Mix it for a few minutes to make sure that all tryptamine is dissolving.

Step 2. Combine Tryptamine Solution with Oxalyl Chloride

Then, you include the oxalyl chlorine to act as a reagent in the formation of indole the oxalyl chloride, which is an intermediary between the beginning substance (tryptamine) in addition to the end result (N,N,DMT). This reaction produces the yellow crystal substance that falls from solution onto in the lower part of the bottle.

Step 3. Add Dimethylamine

A dimethylamine-like compound is later added to the reaction of indole Oxalyl Chloride. This forms the next chemical intermediary called indol-3-yl-N,N-dimethyloxylamide.

Mix the solution for several moments until the white powder appears in the base of the bottle.

Step 4: Discard the White Substance from the Liquid

Clean the entire mixture to eliminate any white material from. Rinse it off with water and ether to get rid of all diethyl ether that is in the mixture and allow it to dry in a cool, well ventilated place.

Step 5: Lithium Aluminum Hydride

Make a solution from lithium aluminum hydride in tetrahydrofuran . mix in the white powder you gathered in step 4.

The entire solution should be refluxed for several hours, then allow it to cool down to ambient temperature. It is necessary to add dioxane to remove any remaining hydroxide during the reaction. The resultant mixture will produce a white sediment that forms on the base of the vessel, which is a mixture of the DMT and a variety of impurities that must be eliminated.

Step 6: Wash, Filter and dry

Remove the mixture by filtering it to get rid of the DMT-containing white powder. Rinse the mixture with tetrahydrofuran many times, then dry the powder with anhydrous magnesium sulfurate.

Step 7: Recrystallize the Impure Powder

The powder you’ve got in this moment has the highest amount of DMT however it’s not 100% completely pure. It has to be cleaned before it can be used.

Dissolve the powder using a solvent such as petroleum ether. Slowly warm it until the mixture has completely dissolvable. Let the solution cool to room temperature and allow the DMT crystals to form. It is possible to put your solution inside the refrigerator in order to allow the DMT to disintegrate from the solution.

Remove the powder from the filter and allow it to air dry in a room that is well ventilated. There isn’t a the pure DMT at this stage.

Step 8: Create DMT Salt

Mix the powder with diethylether (anhydrous) along with hydrochloride (anhydrous). This creates N,N,DMT Hydrochloride which is the end product from this process. It’s an DMT salt that will remain stable for a long time. Remove the filter and allow the powder to dry.

Step 9: Rerystallize Once Again

Mix the powder with either benzene or methanol, and gently heat. When the powder has completely dissolving, take it off the heat and let it cool. DMT hydrochloride is slowly beginning to form crystals in the container. It is then filtered and dried with air for the final time.

The final product is (nearly) pure N,N,dimethyltryptamine hydrochloride.


Making DMT isn’t terribly difficult but it requires the use of extremely toxic and flammable ingredients. It’s essential that anyone attempting to create the substance is aware of the dangers involved and how to limit the risk.

Even in fully-equipped laboratories there are still mistakes that could (and could) cause fires, explosions, and possibly fatal exposure to harmful chemicals.

Here are some essential things to consider when working in a lab

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1. Always wear gloves and safety Goggles

Many of the chemical components involved in the extraction and creating DMT contain or acidic (causes chemicals to burn) or toxic or flammable. each of these motives are good reasons to wear protective clothing to protect yourself from injuries from accidental exposure.

You may think that these safety precautions aren’t crucial since you’ve “never experienced an incident previously,” it’s an untrue assumption that you do not need to master by doing it the hard way. Even if you’ve never had an incidents in the past, doesn’t mean it’s unlikely to be a possibility in the near future.

Inhaling any of these substances in the lung or on the skin or even in the eyes could cause permanent damage to the eyes, skin, or lungs.

2. Make Sure You’ve Got Proper Ventilation

Solvents such naphtha are very flame-proof. Certain steps involve heating the ingredients which causes their vaporization into air. If there’s not enough airflow to eliminate these substances from the air and are inhaled, they could be absorbed (toxic) or ignite an ignition source or spark that can cause an explosion and resultant sparks of fire.

It’s recommended to carry out these actions in a workshop equipped with HVAC systems or at least , have the garage door smashed open and the fan blowing air from the garage’s interior towards the outside.

3. Know the chemicals you’re using

A few of the chemicals listed that are listed in the above recipe lists are available in store-bought chemicals such as Draino. But these cleaning agents aren’t 100% pure. Other ingredients could cause harm or the creation of harmful byproducts.

It is recommended to use lab-grade chemicals as often as you can and be aware of the steps you’ll be following before beginning.

4. Do not heat your Solvents with an Open Fire

Similar to the second point, should any of the solvents which evaporate into the atmosphere reach an ignition source or ignite (including sparks generated by static electricity) and ignite, they can cause an ignition. Before beginning, be sure that there aren’t any sources that could ignite (such as the stovetop or a heater) Don’t smoke, and don’t utilize your vaporizer — absolutely nothing.

5. Check Your Final Product Prior to You Use It

Even the top chemists around the world will test each final item to make sure that it’s completely authentic. Although those who perform DIY extractions at home are unlikely to have access mass spectrometry machines however, there are other techniques, less refined, to ensure that the product is what the manufacturer believes they are.

Purchase some harm-reduction reagent kits to test a small amount of your product after you’re finished. This will not prove the quality of the final product however it can ensure that you didn’t go over the line completely and get something entirely different.

the chemical structure of DMT

DMT can be classified as an alkaloid indolethis is the same classification used for other psychoactive substances, such as LSD (lysergic acid diethylamide) and Psilocybin ( magic mushrooms). It’s also the basic structure of amino acid tryptamine along with serotonin and Melatonin.

There are more than 4000 indole alkaloids that exist and many have pharmacological activity in humans.

The basic form of indolealkaloids an amalgamation of a six-sided the benzene ring that is that is bonded to a 5-sided pyrrole rings.

The DMT molecules are one of the most basic psychoactive compounds that are known. Its molecular weight is just a little more than glucose. Its tiny size allows it to pass through the blood-brain barrier more easily than other psychedelics.

The history of DMT Production

The first type of DMT extraction is directly from Amazon with the name of Ayahuasca. Ayahuasca is water extracts of DMT from native plant species, and also a variety of harmala alkaloids that come from the ayahuasca plant ( Banisteriopsis caapi).

The first time that N,N,DMT was synthesized in a laboratory took place in 1931, by Canadian chemical engineer Richard Helmuth Frederick Manske. In the beginning, Manske did not know that that the chemical he created could cause psychoactive effects.

In 1946 Brazilian chemical chemist Oswaldo Goncalves de Lima identified N,N,DMT within the barks of Mimosa hostilis..

In the present, there are numerous studies that have highlighted innovative techniques or developments in the manufacturing of synthetic DMT and its extraction.

Large-Scale DMT Production

The techniques described above are the simplest methods to create DMT however, they’re not necessarily the most efficient methods on an extensive scale.

A paper published in the latter part of 2020 did a fantastic job of describing the techniques used to make 5-MeO-DMT in large quantities. These techniques maximize the effectiveness and consistency of the production between batches rather than focusing on the cheapest or simplest.

This report provided three methods to synthesize 5-MeO DMT from various starting materials:

1. Modified Eschweiler-Clarke Reaction

  • Single-step reaction
  • Simple process
  • Very difficult to manage

This is the single-step procedure described earlier, as well as used by Hamilton Morris in his demonstration of 5-MeO DMT synthesizing.

It’s quite simple to use however it requires the availability of 5-MeO-tryptamine as a base material, which is legal and readily accessible commercially. The bulk of the work has been completed in the creation of the precursor, therefore an easy reduction reaction is required to transform the molecule to 5-MeO-DMT.

2. The Speeter-Anthony Tryptamine Synthesis

  • >90% conversion efficiency
  • Very difficult to build
  • Requires oxygen-sensitive ingredients

This is the most commonly used method that is cited in scientific literature. It’s used for the production of various psychoactive tryptamines like Psilocin and psilocybin. The process is currently becoming less popular in favour using the Fischer indole reaction since it’s simpler to scale.

3. This is known as the Fischer Indole Reaction

  • 80% conversion efficiency
  • Single-step procedure
  • There aren’t any high temperatures
  • Occurs in aqueous solvents
  • It can be used to both 5-MeO and N,N,DMT.

This is the most efficient method for large-scale production since it’s scaleable, only requires one step of reaction, doesn’t require extreme temperatures (less hazardous) It occurs in an aqueous solvent doesn’t require air-sensitive or pyrophoric reactions and utilizes easy, readily available components.

How to Utilize DMT

The DMT resulted from the processes above outlines leaves you with very fine, brownish to white powder. Here’s how to make use of Freebase DMT powder:

1. Vape It

Vaporizing DMT is the most straightforward way to utilize it. There are two primary methods to accomplish this:

Create a DMT-charged E-Liquid -Create a DMT-charged E-Liquid –dissolve this powder in the base of an E-liquid (readily accessible on the internet) after which you fill your E-liquid vape pen using the DMT-charged E-juice. It is possible to make the juice whatever strength you like however, the most commonly used ratio is 1:1. That means that you need to add around 1 gram of DMT powder for each milliliter of E-liquid.

Smoke raw DMT powder using the form of a mesh or mod penThese devices have a stainless steel mesh which keeps the powder in place above that heating component. This is the most effective method to achieve breakthroughs with a single hit. However, these gadgets are more costly and require some tweaking working correctly.

2. Smoke It

DMT is a smokeable substance that can be used through a bong or pipe. It’s extremely hard no matter what the smoke is taken. Many prefer using crack-style pipes for smoking DMT since they are able to regulate the temperature better than having to place the fire directly onto it.

Don’t utilize DMT powder without measuring it first. The powder is extremely durable.

3. Eat It

If you consume DMT powder by mouth it will not cause any harm. It is necessary to blend it into a monoamineoxidase inhibitor prior to it being able to perform its function.

This is a tricky business that no one should undertake without sufficient expertise and guidance from experienced users. There are two types of MAO inhibitors that you should consider herbal MAO inhibitors as well as medical MAO inhibitors.

The main ingredient used to achieve this is referred to as Pharmahuasca. It’s an attempt to simulate ayahuasca with synthetic substances. This involves mixing DMT with prescription MAO inhibitor such as Isocarboxazid (Marplan). This can be dangerous -it could be dangerous – Marplan is a potent drug that has a number of possible side consequences.

Herbal choices are Syrian Rue and Ayahuasca vine. These can make extremely strong tea and then mixed with DMT. The effects of this method will vary greatly from in no way psychoactive, to being highly psychoactive.

Final Ideas: How to Make DMT

Making DMT is much easier than you’d think. The most straightforward way to make it is by extracting it and extract it from plant material however it is also synthesized with relatively basic chemicals.

In the ideal scenario, a single lab could create enough DMT to cover every continent. The process is currently being studied that can produce 5-MeO DMT and N,N with an efficiency of more than 80 percent.

It’s crucial that we establish the standards for DMT production earlier than it goes out of hand. In the past once substances become popular, all kinds of unsavory players are introduced to the market. The manufacturers might not be able to maintain the same level of honesty in their manufacturing processes as we would like. This could lead to dangerous quality, adulterated, or unreliable DMT being sold on the market.